References:
1. Probiotics as a Potential Immunomodulating Pharmabiotics and Allergic Diseases: Current Status and Future Prospects. Allergy Asthma Immunol Res. 2018 Nov; 10(6): 575–590. Published online 2018 Jul 6 ... read more
2. Hamelmann E, Schwarze J, Takeda K, OshibaA, Larsen GL, Irvin CG, Gelfand EW. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am. J. Respir. Crit. Care. Med. 1997;156: 766–775 ... read more
3. Hougee S, Vriesema A.J.M., Wijering S.C., Knippels L.M.J., Folkerts G., Nijkamp F.P., Knol J., Garssen J. Oral treatment with probiotics reduces allergic symptoms in ovalbumin-sensitized mice: a bacterial strain comparative study. Int. Arch. Allergy. Immunol. 2010;151:107–117...read more
4. Safety Evaluation of Multiple Strains of Lactobacillus plantarum and Pediococcus pentosaceus in Wistar Rats Based on the Ames Test and a 28-Day Feeding Study ... read more
5, Multispecies probiotics combination prevents ovalbumin-induced airway hyperreactivity in mice, Allergologia et Immunopathologia. Volume 46, Issue 4, July–August 2018, Pages 354-360, ... read more
Provides support for your pets innate immune system against allergens and atopic skin conditions like yeast, fungal and bacterial infections.
INGREDIENTS
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18 billion CFU
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L. plantarum LP109
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L. plantarum LP110
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P. acidilactici PA320
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B. subtilis natto BSN287
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It is also dairy-free, soy-free and gluten-free to ensure tolerability in individuals with food allergies.
EFFICACY TEST AND REPORTS
Probiotics have shown to be able to:
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Strengthen the biological defensive barrier
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Regulate bioactivity of immunocytes
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Promote the bioactivity of Th1 cells under allergic condition
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Inhibit the bioactivity of allergic path of Th2 cells
All these factors work in tandem to correct immunoreactions to a balanced state.
This product has passed the Microbial Heavy Metal and Pesticide residue test. View certification, Product data sheet and Antibiotics susceptibility chart.
Test Results of and anti-allergic Modulatory Effects
Allergic reactions are related to a group of immunocytes, called as T-cells. They are divided in three types - Th1, Th2 and Treg. Under normal conditions, the Th1 and Th2 will work in-tandem, while being modulated by Treg, to maintain a balance and control reactions.
When exposed to different of allergens, the body reacts and the Th2 cell in body will increase. This may induce B cells to produce more allergic antibodies, such as IgE, thus leading to allergic reactions. Keeping the balance between Th1 and Th2 is key to maintaining a well balanced body system.
Without causing immunosuppression of immunocytes (i.e. phagocytes and NK clees), IMMUNE+ can activate the Th1 path (i.e. the production of cytokino IFN-γ), and minimize the path of Th2 [i.e. the production of cytokino IL-4 and IL-5, and the expression of CD278+ and CD4+ (Th2 cell)], to attain immunobalance that Prevents attenuating allergic reactions.